Creating a New EndNote Library:
1. In EndNote, select File → New
2. Select where you want to save the library
3. Type the name of your new library
4. Click Save
More details about libraries:
The number of references you can have in a library is unlimited - but it is best to keep it under 100,000.
You can create any number of libraries.
Libraries created on a PC can be used on a Mac, and vice versa.
It is very important to periodically back up your EndNote libraries. To do this: